Introduction to Indirect Coombs Test
The indirect Coombs test, also known as the indirect antiglobulin test, is essential in prenatal care and blood transfusion scenarios. It helps detect antibodies that could cause complications.
How the Test Works
In this test, a blood sample from the patient is mixed with donor red blood cells. If antibodies are present, they will attach to the donor’s red blood cells. An anti-human globulin is then added to observe any agglutination.
Applications and Importance
The indirect Coombs test is crucial in identifying Rh incompatibility in pregnant women, preventing hemolytic disease of the newborn. It is also used to ensure the safety of blood transfusions by detecting potentially harmful antibodies in the donor’s blood.


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